2022 NFL Playoffs: San Francisco 49ers vs. Green Bay Packers NFC Divisional Round Betting Odds, Preview, and Picks

49ers vs Packers 2022 div rd

Familiar NFC rivals face off once more as the San Francisco 49ers take on the Green Bay Packers for the fourth time over the last two seasons. The Packers have won the two most recent meetings, but it’s been the Niners who’ve gotten the last laugh in their latest postseason battles. Who’ll come out on top of this massive showdown in Lambeau Saturday night?

Read on for our odds and preview for the San Francisco 49ers vs. Green Bay Packers NFC Divisional Round matchup below. And to be on top of all the developments from the 2022 NFL Playoffs and beyond, head on over to Nitrogen Sports Blog after this.

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2022 NFL Playoffs: San Francisco 49ers vs. Green Bay Packers NFC Divisional Round preview and odds 

Where: Lambeau Field, Green Bay, WI
When: Saturday, December 22, 2022, 8:15 PM ET
Odds: San Francisco 49ers (+6) at Green Bay Packers (-6); total: 47.0
Where to Watch: CBS

What to know about the San Francisco 49ers

San Francisco 49ers vs. Green Bay Packers betting odds for San Francisco: +6

Although their 23-17 win over the Dallas Cowboys in the Wild Card Round was laden with officiating controversies and relatively lackluster play, the San Francisco 49ers still hung on to their lead and ultimately advanced to the Divisional Round. This keeps the Niners’ streak of six straight playoff appearances with wins in each of their opening-round matchups alive dating back to 2002.

A huge concern for San Francisco heading into Lambeau is the status of starting quarterback Jimmy Garoppolo. The veteran signal-caller went just 16-of-25 for 172 passing yards and a costly interception against Dallas, and Garoppolo also injured his shoulder during that contest. 

Although Jimmy G is expected to start versus the Packers nursing said injury, the Niners should still lean on their prolific run game thanks to the dynamic duo of rookie running back Elijah Mitchell and All-Pro, multi-talented wideout Deebo Samuel. Mitchell and Samuel combined for 168 rushing yards with each of them finding the end zone against the Cowboys, as San Fran looks to exploit a beatable Green Bay run defense.

What to know about the Green Bay Packers

San Francisco 49ers vs. Green Bay Packers betting odds for Green Bay: -6

Thanks to having the best record in the NFL at end of the regular season, the Green Bay Packers have had plenty of time to gather themselves for yet another strong playoff run. The Packers won five of their last six regular-season contests, opting to rest most of their starters in the Week 18 loss to the Lions.

Aaron Rodgers appears in line to win back-to-back league MVP awards after throwing for 4,115 yards and 37 passing TDs to just four interceptions all season long. The Packers boast a top-10 offense, one that ranked 10th in the league both in yardage (365.6 YPG) and points scored (26.5 PPG) on the strength of Rodgers’ top weapons in wideout Davante Adams and starting back Aaron Jones.

Green Bay’s defense, on the other hand, isn’t as imposing as many believe it is given the team’s success this year, ranking 14th during the regular season in yards and points allowed. On the bright side, standout defenders in cornerback Jaire Alexander (shoulder) and linebacker Za’Darius Smith (back) are expected to make their long-awaited returns to the field. Alexander has not seen action since Week 4, while Smith will be making his first start since the opening week of the regular season.



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San Francisco 49ers vs. Green Bay Packers betting trends

  • San Francisco is 3-0 in its last three postseason meetings against the Packers (2-0-1 ATS). The team is also 5-2 in its last seven road games (SU/ATS).
  • Green Bay is 14-1 at home since November of the 2020 season, including the playoffs (11-4 ATS). The team is 4-2 in its last six games as favorites to win, albeit with a 2-4 record against the spread in those contests.

Where to make San Francisco 49ers vs. Green Bay Packers picks

San Francisco 49ers vs. Green Bay Packers odds are available at Nitrogen Sports. Create a free Nitrogen Sports account to start placing stakes on all the smash-mouth action from the NFL gridiron right now. 

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What’s your San Francisco 49ers vs. Green Bay Packers Divisional Round prediction?

A well-rested, well-prepared Packers side deserves the upper hand in this massive Wild Card matchup. Then again, the Niners have had Green Bay’s number in the postseason and don’t really have any glaring weaknesses that the Packers could exploit. As such, we wouldn’t be surprised if the 49ers manage to cover the spread or even outright upset Green Bay on Saturday night to hand Rodgers yet another failed run at his second Super Bowl win.

Be sure to read our NFL betting guide to get you ready for the 2022 NFL Playoffs’ wagering action. To keep up on the latest NFL offseason news, make sure to head on to our NFL Hub here on the blog.

*All stated odds are subject to change without prior notice.

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