The 3 Most Important 2021 NFL Season Games in Week 18

The biggest regular season in NFL history, literally, is in its final stretch, as the league’s first-ever Week 18 will kick off on Saturday and will end on the first Sunday of the new year. Not only will NFL fans be treated to one extra week of football, but the AFC and NFC playoff pictures will also be decided with a handful of games having huge implications in the season finale. 

That being said, let’s take a look at the three most important games on Week 18’s slate, as well as the odds and short previews for these three marquee matchups. And to be on top of all the developments from the ongoing 2021 NFL season and beyond, head on over to Nitrogen Sports Blog after this.

Dallas Cowboys vs. Philadelphia Eagles

Where: Lincoln Financial Field, Philadelphia, PA
When: Saturday, December 8, 2022, 8:15 PM ET
Odds: Dallas Cowboys (-7) at Philadelphia Eagles (+7); total: 42.5

Although there’s not much at stake in terms of playoff implications, this NFC East showdown between playoff-bound franchises Dallas and Philadelphia is still a must-watch and rare primetime Saturday affair.

The Cowboys are eagerly awaiting their first-round opponent, and so too are the Eagles at this point. The two division rivals likely won’t cross paths until late in the postseason given their respective playoff seedings even after Week 18’s action. That just makes this one final meeting between the NFC East’s best that much more entertaining to follow.

San Francisco 49ers vs. Los Angeles Rams

Where: SoFi Stadium, Inglewood, CA
When: Sunday, December 9, 2022, 4:25 PM ET
Odds: San Francisco 49ers (+5) at Los Angeles Rams (-5); total: 44.0

Things over in the West Coast are much more pivotal, as the upcoming clash between the 49ers and the Rams will decide the former’s fate. The Niners, who have a five-game win streak to date against their California rivals, need to beat the Rams to guarantee their playoff spot. 

A Los Angeles loss coupled with a win by Arizona would also have the Cardinals soar over the Rams for the NFC West division title. San Francisco can still make the postseason should they lose their final game of the regular season if New Orleans loses to Atlanta this weekend as well.



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Los Angeles Chargers vs. Las Vegas Raiders

Where: Allegiant Stadium, Paradise, NV
When: Saturday, December 8, 2022, 9:20 PM ET
Odds: Los Angeles Chargers (-2.5) at Las Vegas Raiders (+2.5); total: 49.5

There’s even more at stake over in the Pacific when the Raiders host the Chargers at Allegiant Stadium in the final game of the 2021 NFL regular season. It’s simple; the winner of this primetime showdown in Sin City will decide which of these two AFC West hopefuls will advance to the playoffs. 

The Raiders are peaking at the right time with a three-game win streak in tow, including last week’s huge win over the playoff-bound Colts. The Chargers, meanwhile, stopped the bleeding with a dominant showing against the Broncos to snap their two-game losing skid; a short yet wild stretch with a tense overtime loss to the mighty Chiefs followed by a lopsided upset to the lowly Texans.

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Be sure to read our NFL betting guide to get you ready for the 2021 NFL season’s wagering action. To keep up on the latest NFL offseason news, make sure to head on to our NFL Hub here on the blog.

*All stated odds are subject to change without prior notice.

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