2022 NFL Playoffs: San Francisco 49ers vs. Los Angeles Rams NFC Championship Game Betting Odds, Preview, and Picks

49ers vs Rams 2022 NFC champ game

Two NFC West rivals meet in the deciding game for the conference title this Sunday night. The San Francisco 49ers did the unthinkable by beating Aaron Rodgers and the top-seeded Packers, whereas the Los Angeles Rams also took down another legendary quarterback with a tight win over Tom Brady and the Buccaneers. Will the Rams end up “hosting” Super Bowl 56 at SoFi Stadium in a couple of weeks from now, or do the Niners have one more upset left in them?

Read on for our odds and preview for the San Francisco 49ers vs. Los Angeles Rams NFC Championship Game below. And to be on top of all the developments from the 2022 NFL Playoffs and beyond, head on over to Nitrogen Sports Blog after this.

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2022 NFL Playoffs: San Francisco 49ers vs. Los Angeles Rams NFC Divisional Round preview and odds 

Where: SoFi Stadium, Los Angeles, CA
When: Sunday, January 30, 2022, 6:30 PM ET
Odds: San Francisco 49ers (+3.5) at Los Angeles Rams (-3.5); total: 46.5
Where to Watch: FOX

What to know about the San Francisco 49ers

San Francisco 49ers vs. Los Angeles Rams betting odds for San Francisco: +3.5

For the second time in three years, the San Francisco 49ers are back in the NFC Championship Game thanks to their stunning upset of the Green Bay Packers this past Saturday, 13-10. San Francisco remains unbeaten against Green Bay for the fourth straight playoff encounter and is arguably the scariest team left in the postseason right now.

The freezing weather in Lambeau Field certainly played a role in the lackluster showing from Niners quarterback Jimmy Garoppolo, who finished with just 11 completions for 131 passing yards and one interception. However, it was the 49ers’ defense and special teams that were impressive at shutting down Arron Rodgers and the Packers’ mighty offense.

San Fran had two blocked kicks, with one of them being returned for a touchdown for the team’s only trip to the end zone the entire contest. The Niners also managed to sack Rodgers five times and forced a fumble off of tight end Marcedes Lewis to swing the tide in the Niners’ favor for the better part of the game, as they held the Packers to just 48 yards of total offense in the second half. 

What to know about the Los Angeles Rams

San Francisco 49ers vs. Los Angeles Rams betting odds for Los Angeles: -3.5

Similar to the 49ers, the Los Angeles Rams needed a game-winning field goal to win their Divisional Round matchup against the Tampa Bay Buccaneers. The Rams escaped Raymond James Stadium with a 30-27 win to deny Tom Brady his 10th trip to the conference championship round over the last 12 years.

Matthew Stafford stayed hot in his second-ever playoff game as a Ram, completing 28 of 38 passes for 366 yards and a pair of touchdowns. It was the regular season’s leading receiver in Cooper Kupp who had another electric outing, as Kupp hauled in nine catches for 183 receiving yards and one of Stafford’s two TD passes.

What’s quite concerning, however, is that LA’s defense nearly blew a 24-point lead by the middle of the third quarter, as the Bucs scored 24 unanswered points themselves before Stafford march his team’s offense down the field with a five-play, 63-yard drive to set up Matt Gay’s game-winning boot as time expired. 



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San Francisco 49ers vs. Los Angeles Rams betting trends

  • San Francisco is 5-2 in road playoff games since 2012 (4-2-1 ATS). The team is also on a six-game winning streak against the Rams (5-1 ATS).
  • Los Angeles is 4-3 in its last seven home games (3-4 ATS). The point total went under in five of those seven homestands.

Where to make San Francisco 49ers vs. Los Angeles Rams picks

San Francisco 49ers vs. Los Angeles Rams odds are available at Nitrogen Sports. Create a free Nitrogen Sports account to start placing stakes on all the smash-mouth action from the NFL gridiron right now. 

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What’s your San Francisco 49ers vs. Los Angeles Rams NFC Championship Game prediction?

Although the Rams’ offense looked much better than that of San Francisco’s own offense this past weekend, we shouldn’t forget that Sean McVay and Co. have not been able to beat the Niners for quite some time now. Having home-field advantage is certainly a plus for LA, but the 49ers’ chances of staging another road upset are at their highest with how well their defense and special teams have been able to bail them out of tight situations this entire postseason. 

Be sure to read our NFL betting guide to get you ready for the 2022 NFL Playoffs’ wagering action. To keep up on the latest NFL offseason news, make sure to head on to our NFL Hub here on the blog.

*All stated odds are subject to change without prior notice.

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